Paper: Ontology-Based Extraction and Summarization of Protein Mutation Impact Information

ACL ID W10-1917
Title Ontology-Based Extraction and Summarization of Protein Mutation Impact Information
Venue Workshop on Biomedical Natural Language Processing
Session
Year 2010
Authors

each on a specific protein family: Xylanase (19 documents), Haloalkane Dehalogenase (23 documents), Subtilisin (5 documents), and Dioxygenase (11 documents). Altogether, 58 documents were manually annotated with their impacts. For each annotation “Sentence,” a binary feature “impact” is considered. As long as an impact exists in the sentence, the feature “impact” PMID 10860737 Mutation Impacts N35D As predicted from sequence comparisons, substitution of this asparagine residue with an aspartic acid residue (N35D BCX) shifts its pH optimum from 5.7 to 4.6, with an 20 % increase in activity.... PMID 8855954 Mutation Impacts E123A Mutation of a third conserved active site carboxylic acid (E123A) resulted in rate reductions of up to 1500-fold on poorer substrates,... strates,... E1...